Aaa+ Chaperone Clpx Regurates Dynamics of Prokaryotic Cytoskeletal Protein Ftsz
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چکیده
AAA+ CHAPERONE CLPX REGURATES DYNAMICS OF PROKARYOTIC CYTOSKELETAL PROTEIN FTSZ Shinya Sugimoto, Kunitoshi Yamanaka, Shingo Nishikori, Atsushi Miyagi, Toshio Ando, and Teru Ogura From Department of Molecular Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan, Department of Physics, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan, and The Takara-Bio Endowed Laboratory, Institute for Protein Research, Osaka University, 6-2-3 Furuedai, Suita, Osaka 565-0874, Japan Running head: ClpX-mediated inhibition of FtsZ polymerization Address correspondence to: Teru Ogura, 2-2-1 Honjo, Kumamoto 860-0811, Japan. Tel: +81-96-373-6578; Fax: +81-96-373-6582; E-mail: [email protected]
منابع مشابه
AAA+ chaperone ClpX regulates dynamics of prokaryotic cytoskeletal protein FtsZ.
AAA(+) chaperone ClpX has been suggested to be a modulator of prokaryotic cytoskeletal protein FtsZ, but the details of recognition and remodeling of FtsZ by ClpX are largely unknown. In this study, we have extensively investigated the nature of FtsZ polymers and mechanisms of ClpX-regulated FtsZ polymer dynamics. We found that FtsZ polymerization is inhibited by ClpX in an ATP-independent mann...
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